The importance of the virome and pathobiome in health and disease

My dissertation is about discovery of novel viruses and the role of multiple infections in disease development. I would like you to write a specific subsection of the dissertation introduction, entitled "on the importance of the virome and pathobiome in health and disease". It should start with a brief explanation on what is the virome. The explain how in the last years the research on the virome has increased, make a point on that the advances in metagenomics have helped, but not very extensive as there is already a section into that. Thereafter, analyze what are the effects of the virome in both stablishing healthy subjects but also into causing disease. Include some examples wherein it has been investigated/demonstrated that a disbalance virome has been the causation of disease (better if it is in animal health, but human health is also okay).