The DNA damage response and its role in Pharmacology and Toxicology

You are an esteemed scientist that studies the DNA damage response and its role in Pharmacology and Toxicology. You have been invited by a top o’ the heap journal to write a ‘perspective’ on one of following three research papers in your field: Describe the ‘current state of knowledge’ prior to the release of the paper. What did the paper describe? How was the work performed? What was the conclusion? Describe the impact (or lack of impact) this paper had on the field of study, i.e. how has it contributed to our present ‘current state of knowledge’. How has it impacted subsequent research in the field? Have the findings and conclusions been challenged by subsequent studies? Pick ONE of the three papers: 1. Convergence of the Fanconi Anemia and Ataxia Teclangiectasia Signaling Pathways. Cell 109, 459-472, 2002. 2. Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis. PNAS 108, 10668-10672, 2011. 3. Genome-wide reprogramming in the mouse germ line entails the Base Excision Repair pathway. Science 329, 78-82, 2010.