Spermatogonial stem cells (SSCs) produce sperm throughout the

Spermatogonial stem cells (SSCs) produce sperm throughout the post-pubertal life ofa male. The self-renewal and differentiation ofthese cells is controlled by glial-cell-line-derived neurotrophic factor (GDNF). Discuss the role of GDNF signalling in the maintenance and differentiation of SSCs.