Clearance
Toxicants are cleared from the body via various routes, for example, excretion by the kidneys into urine or via bile into the intestine ending in feces, biotransformation by the liver, or exhalation by the lungs. Clearance is an important toxicokinetic parameter that relates the rate of toxicant elimination from the whole body in relation to plasma concentration (Wilkinson, 1987). Although terminal T1/2 is reflective of the rate of removal of a toxicant from plasma or blood, it is also subject to the influence of distributional processes, especially for toxicants exhibiting multicompartmental kinetics. Clearance is a parameter that solely represents the rate of toxicant elimination; it is not influenced by extravascular distribution.
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